The new Tandem gas analyser data capture software allows the convenient monitoring and visualisation of exhaust gas data from all Tandem Gas Analysers
Advantages of the Tandem data capture software:
| Real-time monitoring of %CO2 and %O2 from the off-gas of any bioreactor
| Export data in CSV format
| Available as a stand-alone portable unit
| Works with any Tandem gas analyser
| Run up to 18 parallel processes
| Simple to use
| Automatically calculates CER, OUR & RQ with HEL BioXplorer systems
The Tandem Family of Gas Analysers offers you sophisticated CO2 and O2 gas measurement at a similar price to your other standard probes and sensors. Formerly the reserve of expensive equipment, you can now afford dedicated, individual, on-line monitoring and control of your processes. You gain the reliability and the flexibility required in your facility. The Tandem Gas Analysers provide portable systems with option of standalone software.
The Tandem gas analysers off the following benefits:
Greater understanding of your cells and processes
| Physiological state measurement on-line
| Scale-up and scale-down predictions
| Batch variation studies: feature analysis
| Metabolic flux analysis and mass-balance calculations
Increase the reliability and repeatability of your processes
| Accurate fed-batch control
| Metabolic activity based feeding
| Repeatable event decisions: induction, infection, harvesting etc.
| Dedicated, continuous, standard signals for all your reactors
| Automatic calculation of RQ, CER, OUR, and RQ
| Integrates to any reactor size (250 ml – 100 m3)
Fast Optimisation & Safe Scale-up – Simular Reaction Calorimeter
Essential tool for process development chemists
HEL’s reaction calorimetry system provides a unique blend of features that are considered indispensable for process development:
| Automation accelerates development, freeing up chemist time
| Repeatable runs independent of operator
| Ease of use including automatic on-line heat release rate results
| Directly enables prediction of cooling duty, thermal hazard and possible methods for risk reduction
The Simular is based around reaction vessels that are easy to use but also match the geometry and performance of large-scale vessels. Designs are available to suit a range of pressures and temperatures.
Cold fingers have been removed (unscrewed) and silicone seals no longer used. Instead, special PTFE plugs are placed in each vial.
This is the only change.
Why Change?- The Benefits
Solvent loss from vials during an experiment is much reduced and reproducibility is improved. Also, chemical compatibility is improved by removal of silicone seals and use of only PTFE.
The operation remains simple.
Older CAT 7 Units
Existing CAT7 units can be updated easily. Cold fingers must be unscrewed by the user (easily done by hand) and a set of PTFE plugs purchased.
Introducing The BioXplorer 100 & BioXplorer 400 Mini-Bioreactor System
The feature rich, modular design with an extensive list of options means the BioXplorer 100 and 400 can be adapted to any application including microbial fermentation, C1 Gas fermentation and mammalian cell culture. These mini-bioreactors provide the ideal platform for bioprocess development and optimisation using 4 or 8 reactors in parallel with fermentation working volumes from 20 ml to 400 ml (depending on c.onfiguration)
The BioXplorer 100
The BioXplorer 100 is a high throughput, bioprocess screening system
designed for fermentation working volumes of just 20ml to 150ml in blocks of 8 individually controlled bioreactors.
Blocks can be combined to give even larger number of parallel reactors.
The BioXplorer 100 boosts productivity and enables rapid screening, process development and full DoE experiments to be performed efficiently.
| Fully automated, high information content screening tool ideal for DOE studies
| Most compact system for optimised use of bench space
| Highly cost effective system for scalable, rapid, high throughput bioprocessing
| Ideal for cell line/strain screening, media optimisation and small scale process development
| Suitable for robotic integration
| Choice of reactor sizes and types including elevated pressure design (5 bar or 10 bar options)
The BioXplorer 400 provides the ideal platform for bioprocess development and optimisation using 4 or 8 reactors in parallel with fermentation working volumes from 50ml to 400ml.
This volume range provides high-quality data for reliable prediction of large scale performance over a wide range of conditions.
The system is highly flexible allows interchangeable use of smaller vessels with working volumes of just 20ml. The smaller vessels are highly suitable for data rich screening campaigns.
| Most versatile bioprocessing platform for bioprocess development and optimisation
| High information content and excellent scalability to large-scale bioreactors
| Reduce media costs and optimise the use of bench space
| Optional elevated pressure design to 10 bar
One challenge faced by researchers in catalyst development is the need to quickly evaluate different catalysts and optimise reaction conditions. However, accessing affordable, high pressure, high temperature screening devices is equally challenging. The HEL CAT blocks:
|Provide an affordable, entry level range of catalyst research tools.
|Are available in 7, 18 or 24 vial configurations the CAT blocks allow primary catalyst screening and basic process
optimisation at relatively low cost.
|Can be used with conventional hotplate stirrers and all gas and pressure fittings are preinstalled.
|Are widely used successfully at many Universities both as research and teaching tools.
|Allows to undertake rapid parallel catalysis and thereby facilitate quicker downstream analysis.
General Motors (GM) recently purchased an iso-BTC after extensive trials with their batteries samples, even though they have adiabatic calorimeters available to them. Here’s why.
Fires and explosions involving Li-ion batteries occur when heat is not removed effectively and leads to a rise in temperature. Thermal management systems are designed to prevent such incidents but can only do so if they are designed to handle the necessary heat load – which raises the question: how can this load be determined?
The answer is HEL’s iso-BTC, which works exactly like a thermal management system except it reports how much heat is being removed while connected to real battery samples. Many companies fail to appreciate the difference in data from an isothermal calorimeter and the more commonly used adiabatic type (such as HEL’s BTC-500 based on the “ARC” principle).
Typical results are plotted below where the heat load (power loss) is shown at three different discharge rates, for the same battery at the same (constant) temperature. The test can be repeated at different temperatures (for example between -40 to + 100C) to determine the effect of weather conditions
We have prepared a FREE application note, which highlights key performance indicators of thermal control data based on isothermal calorimetry, which can be found here or copy and paste the link below in your browser http://helgroup.com/marketing/isothermal
This webinar focuses on the use of multiple (parallel) reactor platforms, which is becoming an established practice in pharma and other sectors as well as the use of DoE to direct the experimental effort and analyze the data. The webinar also highlights the results of many different process development studies to illustrate the range of parallel reaction instruments available.
Examples from synthetic organic chemistry in general, as well as heterogeneous catalysis (including hydrogenation in flow reactors) and crystallization studies, are used to describe the benefits of these techniques.
Faster and Better Process Development Using Parallel Reactor Platforms and DoE.
Competitive pressures within the chemical process industry require that more processes be developed quickly and with better results.
The use of multiple (parallel) reactor platforms is becoming an established practice in pharma and other sectors as well as the use of DoE to direct the experimental effort and analyze the data. This webinar will present the results of many different process development studies to illustrate the range of parallel reaction instruments available.
Examples from synthetic organic chemistry in general, as well as heterogeneous catalysis (including hydrogenation in flow reactors) and crystallization studies, will be used to describe the benefits of these techniques.
A successful industrial crystallisation requires the development of a robust process in the laboratory. Knowledge of the solubility curve and the stability of the solution in the vicinity of the equilibrium point, as indicated by the metastable zone width (MSZW), are essential to the successful development, optimisation and scale-up of a crystallization process.
HEL has developed a highly sensitive turbidity-based probe to determine both the solubility and recrystallization temperatures automatically. This technology can be supplied either as a stand-alone probe (CrystalEYES) to be used with samples and vessels supplied by the user or else integrated into a multi-sample parallel tool (CrystalSCAN).
The CrystalSCAN can automatically conduct 8 different experiments simultaneously. Specific cooling and heating regimes and automated dilution, to allow different concentrations, can be performed simultaneously and in a fully automated manner reducing weeks of development work to hours.
Pressure relief of chemical reactors is the accepted way to prevent explosive vessel rupture in the event of a control problem such as loss of cooling supply or agitation failure. When the problem leads to a runaway reaction, potentially leading to rapid rises in temperature and pressure, correct sizing of the pressure relief device becomes much more critical due to the potential severity of the incident but also more difficult as it requires an accurate description of the runaway event.
The underlying technology for this was established ~ 1985 through a multi-company initiative (called DIERS). In addition, the need for small-scale simulation of the runaway reaction was established and the characteristics of the instrument to do this were specified. HEL’s Phi-TEC II adiabatic calorimeter follows directly from the findings of DIERS and provides data that can be used for sizing