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Obtaining Better Information From Simple Ramped Temperature Screening Tests
Thermal screening of materials is a vital part of hazard assessment in the chemical industry. There is the need to identify the worst potential hazards and to further investigate these scenarios. Several screening methods are presented, and the subject of ramped temperature screening tests is studied in detail.
Scale Up Of Hazardous Chemistry- With Thermal Runaway Potential
This paper describes (with examples) how with a range of experimental methods and with the correct equipment, it is possible to simulate a thermal runaway. The data produced (with samples less than 100ml) can help prevent potential hazards. (As published in Chemistry Today)
The Design of Safe Chemical Processes
A typical process in the pharmaceutical and related industries consists of a number of sequential steps where a range of carefully selected compounds are allowed to react in order to produce the required product or intermediate. In many cases, the reactions involved are exothermic, and therefore require cooling and careful process control in order to ensure safe operation. In addition, some of the raw materials or products may be unstable and have a tendency to thermally explode under certain operating conditions.
The limitations of DSC as a tool for thermal screening are discussed and the Thermal Screening Unit (TSU) is described. Ramped temperature experimental data for families of experiments on di tertiary butyl peroxide in toluene and azobis cyano valeric acid in dimethyl formamide are presented and used to illustrate the absolute necessity of recording pressure as well as temperature during any thermal screening tests.
TSU: A Tool for Reactive Chemical Engineering
The thermal screening unit is an instrument specifically designed for the fast and efficient hazard screening of liquids, solids and heterogeneous systems. The unit provides an alternative device to DSC and DTA for use in hazard assessment and provides information regarding reaction “onset temperatures”, rates of temperature rise as well as crucial information regarding the rates and magnitudes of pressure rise in chemical systems.