Chemical Synthesis Reactor Systems

Thermal hazard assessment of cyclohexane-type liquid crystal monomer from the Grignard cross-coupling reaction by different calorimeters

Palladium-catalyzed synthesis of carboxylic acid anhydrides from alkenes

Automated Measurement of Metastable Zones for Pharmaceutical Compounds

On-line monitoring of batch cooling crystallization of organic compounds using ATR-FTIR spectroscopy coupled with an advanced calibration method

ReactNMR and ReactIR as Reaction Monitoring and Mechanistic Elucidation Tools: The NCS Mediated Cascade Reaction of α-Thioamides to α-Thio-β-chloroacrylamides

Decomposition of 3-chlorophenol on nitrogen modified TiO2 photocatalysts

The role of adsorption in decomposition of dyes on TiO2 and N-modified TiO2 photocatalysts under UV and visible light irradiations

Empirical Kinetics Equation of the Synthesis of NTO in Nitric Acid

Fast Method for Testing the Photocatalytic Performance of Modified Gypsum

Improved Self-Cleaning Properties of Photocatalytic Gypsum Plaster Enriched with Glass Fiber

Measuring the Particle Packing of l-Glutamic Acid Crystals through X-ray Computed Tomography for Understanding Powder Flow and Consolidation Behavior

Understanding the agglomerate crystallisation of hexamine through X-ray microscopy and crystallographic modelling

Use of isoperibolic reaction calorimeter for the study of reaction kinetics of acetic anhydride hydrolysis reaction: Effect of acetic anhydride and water ratio

Determination of the onset of crystallization of N1-2-(thiazolyl) sulfanilamide (sulfathiazole) by UV-Vis and calorimetry using an automated reaction platform

Towards Improved Reaction Runaway Studies: Kinetics of the N-Oxidation of 2-Methylpyridine Using Heat-flow Calorimetry

Scale-Up of a Vilsmeier Formylation Reaction: Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory

On-Line Monitoring of a Crystallization Process

Use of reaction calorimetry in thermal risk assessment studies and safe design of batch reactions that can lead to a runaway: application on hydrogen peroxide

Modeling the Precipitation of l-Glutamic Acid via Acidification of Monosodium Glutamate

Towards an Information-Rich Process Development. Part I: Interfacing Experimentation with Qualitative/Semiquantitative Modelling

Thermal Behavior of Aqueous Solutions of Hydroxylamine During Isothermal and Isoperibolic Decomposition in a Closed System

The influence of oscillations on product selectivity during the palladiumcatalysed phenylacetylene oxidative carbonylation reaction

Fuzzy logic and rigid control of a seeded semi-batch, anti-solvent, isothermal crystallizer

Adaptive MIMO neuro-fuzzy logic control of a seeded and an unseeded anti-solvent semi-batch crystallizer

A Practical Method For Stabilizing Lithiated Halogenated Aromatic Compounds

Isothermal decomposition of hydroxylamine and hydroxylamine nitrate in aqueous solutions in the temperature range 80–160 ◦C

Utilising high throughput technologies for the determination of the reaction network of the L-proline catalysed aldol reaction

A New Autocatalytic Thioacetate-Enal Addition Reaction: A Michael Addition or Not?

Reaction calorimetric analysis of batch cooling crystallization processes: studies of urea in supersaturated water–methanol solutions

Toward an inherently safer design and operation of batch and semi-batch processes: The N-oxidation of alkylpyridines

Inherently safer reactors: Improved efficiency of 3-picoline N-oxidation in the temperature range 110–125 °C

Oscillatory carbonylation of phenylacetylene in the absence of externally supplied oxidant

The effect of using a methanol–water solvent mixture on pH oscillations in the palladium-catalyzed phenylacetylene oxidative carbonylation reaction

A study on the scale-up of acyl azide synthesis in various continuous flow reactors in homogeneous and biphasic systems

On the Breakage of High Aspect Ratio Crystals in Filter Beds under Continuous Percolation

Thermal hazards evaluation of the synthesis of N-methylmorpholine-N-oxide

Polymorph and Particle Size Control of PPAR Compounds PF00287586 and AG035029

Development of Scaffold Synthesis for the Preparation of New Insulin-Like Growth Factor 1 Receptor Inhibitors

Study of System Thermodynamics and the Feasibility of Chiral Resolution of the Polymorphic System of Malic Acid Enantiomers and Its Partial Solid Solutions

Deactivation and regeneration of ruthenium on silica in the liquid-phase hydrogenation of butan-2-one

Oligomerisation of linear 1-olefins using a chlorogallate(III) ionic liquid

Crystal Product Engineering in the Seeded Cooling Crystallization of Adipic Acid from Aqueous Solution

A novel technique combining high-resolution synchrotron x-ray microtomography and x-ray diffraction for characterization of micro particulates

Comprehensive kinetic model for the dissolution, reaction, and crystallization processes involved in the synthesis of aspirin

Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors

Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole

Rheological and Hydrogenation Study using a Flow Modified Sponge Ni Catalyst

Investigation of pH Effect on Hydrogenation Reaction of Dextrose to Sorbitol using a Mo promoted Sponge Ni catalyst

In-Process ATR-FTIR Spectroscopy for Closed-Loop Supersaturation Control of a Batch Crystallizer Producing Monosodium Glutamate Crystals of Defined Size

Monitoring and Feedback Control of Supersaturation Using ATR-FTIR to Produce an Active Pharmaceutical Ingredient of a Desired Crystal Size

Real-Time Measurement of the Growth Rates of Individual Crystal Facets Using Imaging and Image Analysis: A Feasibility Study on Needle-shaped Crystals of L-Glutamic Acid

Particle Shape Characterisation via Image Analysis: from Laboratory Studies to In-process Measurements Using an in Situ Particle Viewer System

In Situ Measurement of Solution Concentration during the Batch Cooling Crystallization of l-Glutamic Acid using ATR-FTIR Spectroscopy Coupled with Chemometrics

Synopsis: In this journal, the in-situ measurement of solution supersaturation associated with the batch cooling crystallisation of L-glutamic acid (LGA) at 500 mL and 20

Crystal Polymorphs and Transformations of 2-Iodo-4-nitroaniline

Synopsis: This journal discusses the full crystal structural characterization of the crystal polymorphs of 2-iodo-4-nitroaniline. The HEL AutoLAB jacketed crystalliser wa

Cellulose-TiO2 nanocomposite with enhanced UV–Vis light absorption

Synopsis: This paper reports the successful preparation of TiO2/N-cellulose nanocomposite in the (cyclohexyl)hexyldimethylammonium acetate–dimethyl sulfoxide solution.

Reduction of CO2 by adsorption and reaction on surface of TiO2-nitrogen modified photocatalyst

Synopsis: This journal discusses the synthesis of a TiO2/N-100 photocatalyst by hydrothermal reaction of amorphous anatase TiO2 and NH4OH at 100 °C. The preparation of t

Demonstrating the Influence of Solvent Choice and Crystallization Conditions on Phenacetin Crystal Habit and Particle Size Distribution

Synopsis: In this paper, phenacetin was used as a model pharmaceutical compound to investigate the impact of solvent choice and crystallisation conditions on the crystal

Methyl tetra-O-acetyl-α-d-glucopyranuronate: crystal structure and influence on the crystallisation of the β anomer

Synopsis: In this journal, methyl tetra-O-acetyl-β-d-glucopyranuronate and methyl tetra-O-acetyl-α-d-glucopyranuronate were isolated as crystalline solids and their cry

Measuring the Particle Packing of L-Glutamic Acid Crystals through X-ray Computed Tomography for Understanding Powder Flow and Consolidation Behavior

Synopsis: This paper presents the morphology of free-flowed and gravity consolidated crystal powder beds of the alpha and beta polymorphic forms of L-glutamic acid, toget

Nucleation kinetics of paracetamol–ethanol solutions from metastable zone widths

Synopsis: In this study, metastable zone width (MSZW) experiments were conducted in order to estimate the nucleation kinetics of the system a cooling crystallisation of p

Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram

Mixed-level supersaturated design application to a robustness study on an organic synthesis

Solid−Liquid Equilibrium of D- and L-Tartaric Acid and Their Importance for Enantioseparation

Effects of Different Organic Acids on Solubility and Metastable Zone Width of Zinc Lactate

Investigation of the Solid-State Polymorphic Transformations of Piracetam

Use of food-grade proteases to recover umami protein–peptide mixtures from rice middlings

Synopsis: This report investigates the effects of enzymatic hydrolysis of food-grade exo and endo-proteases, Umamizyme and Flavourzyme, on the sensory characteristics and

One-pot combination of enzyme and Pd nanoparticle catalysis for the synthesis of enantiomerically pure 1,2-amino alcohols

Synopsis: This journal reports the one-pot combination of alcohol dehydrogenase-catalysed asymmetric reduction of 2-azido ketones and Pd nanoparticle-catalysed hydrogenat

Synthesis, characterization and performance of bifunctional catalysts for the synthesis of menthol from citronellal

Synopsis: This paper describes the synthesis of a series of bifunctional catalysts (1 wt% Pt/W-TUD-1 and 1 wt% Pt/WO3/TUD-1) with different tungsten loadings (5-30 wt% WO

Influence of Process Parameters on the Heterogeneous Nucleation of Active Pharmaceutical Ingredients onto Excipients

Synopsis: In this work, acetaminophen (AAP), α/β-lactose (α/β-Lac), and methanol (MeOH) were selected as the model active pharmaceutical ingredient (API), excipient,

Formation mechanism of aroma compounds in a glutathione-glucose reaction with fat or oxidized fat

Synopsis: In this journal, glutathione (GSH) and glucose with or without chicken fat/oxidized chicken fat were thermally reacted for generation of stewed meat-like aroma.

Enantioselective Synthesis of a γ-Secretase Modulator via Vinylogous Dynamic Kinetic Resolution

Synopsis: This paper describes two new efficient asymmetric routes to form γ-secretase modulator BMS-932481, under investigation for Alzheimer’s disease. The key step

Tailoring morphology and bulk density of magnesium ethoxide particles by adding n-hexane and silicone oil

Synopsis: In this work, the preparation of magnesium ethoxide (Mg(OEt)2) particles was tailored, using the inert substances silicone oil and n-hexane to control the solve

Rapid synthesis of sodium-rich Prussian white for Sodium-ion battery via a bottom-up approach

Synopsis: This journal proposes a bottom-up approach to afford rapid and productive preparation of NaxMn[Fe(CN)6]y (MnHCF) with the low defect and high sodium content, by

Structural analysis of metastable pharmaceutical loratadine form II, by 3D electron diffraction and DFT+D energy minimisation

Synopsis: This article reports the determination of the crystal structure of the metastable form II of loratadine using a combination of low-resolution 3D electron diffra

Scale-Up of a Vilsmeier Formylation Reaction:  Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory

Synopsis: The journal describes the application of reaction calorimetry and process modelling to allow for rapid and safe scale-up of a Vilsmeier formylation reaction, wh

Isothermal reaction calorimetry as a tool for kinetic analysis

Synopsis: This paper reviews the most important reaction calorimetric principles and their application in commercial or scientific devices, giving examples of various rea

Thermal Hazards of the Vilsmeier−Haack Reaction on N,N-Dimethylaniline

Achieving pH and Qr oscillations in a palladium-catalysed phenylacetylene oxidative carbonylation reaction using an automated reactor system

Synopsis: This experimental shows evidence for oscillations in both pH and heat output (Qr) during a palladium-catalysed phenylacetylene oxidative carbonylation reaction

Control of Supersaturation in a Semibatch Antisolvent Crystallization Process Using a Fuzzy Logic Controller

Kinetics Estimation and Single and Multi-Objective Optimization of a Seeded, Anti-Solvent, Isothermal Batch Crystallizer

Synopsis: This journal estimates the nucleation and growth kinetic parameters of paracetamol in an isopropanol-water antisolvent batch crystalliser, by nonlinear regressi

The influence of reaction temperature on the oscillatory behaviour in the palladium-catalysed phenylacetylene oxidative carbonylation reaction

Autonomous reorganization of the oscillatory phase in the PdI2 catalyzed phenylacetylene carbonylation reaction

Synopsis: The PdI2 catalyzed oxidative carbonylation of phenylacetylene has been shown to produce pH oscillations over the temperature range 0-40 °C under semi-batch con

Thermal Hazards of Synthesizing a Grignard Reagent under Different Dosing Rates

Critical Assessment of Pharmaceutical Processes A Rationale for Changing the Synthetic Route

Synopsis: This review was written as an analysis of the issues in creating a synthetic route for the pharmaceutical industry. It groups these issues into 6 categories: Sa

Concentration and Separation of Heavy Rare-Earth Metals at Stripping Stage

Synopsis: This work investigates the separation and concentration processes of heavy rare-earth metals (HREM) yttrium, ytterbium, erbium, and dysprosium during stripping