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Design Of Experiment DOE
Statistical Design of Experiments (DoE) is widely recognized as the most effective approach for process development.
Application of this technique can take a long time – weeks or even months – unless the right experimental tools are available so that quality results can be obtained at speed. The best tools consist of multiple reactors that can work in parallel as well as independently with accurate control and logging of all key parameters.

HEL has a range of parallel chemistry platforms (4 and 8 reactor set ups as standard) which include applications such as:
-Heterogeneous catalysis under pressure (e.g for hydrogenations) – HP ChemScan
-General synthetic chemistry at wide temperature ranges in compact footprint – PolyBlock
-More challenging set of controls and/or extreme working range and flexibility – AutoMate II

These systems are fully computer controlled and if necessary can be linked directly to the DoE software so that process conditions can be easily entered for the different runs. This is the first step towards eventually having a closed loop optimisation platform.
Click HERE to download our white paper (in conjunction with the University of Nottingham)  on the:
 “Conversion of isophorone to trimethylcyclohexanone”, which highlights the application of DoE
software, for the optimisation of continuous flow hydrogenation
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