FREE WHITE PAPER DOWNLOAD
Robotic culture platform with HEL minibioreactors
Parallel platforms can also be integrated with bioreactors – hence 4 or 8 reactor parallel stations are now possible with a compact footprint that includes all the features of high specification applications – pH, DO, agitation, liquid dosing, independent temperature control.
A recent project extended this concept still further with a set of 24 independent reactors for TWB in France, involving the integration of a
Hamilton robot and HEL bioreactor system.
The final design – a “culture robot” – allows, among other things, identification of optimal culture conditions or generation of successfulstrains, in less than a fifth of the time taken with conventional automated reactor systems. This platform is well suited for microbial culture and enzyme catalysis –Click here to download our case study OR or copy and paste this link: http://bit.ly/heltwa1
Statistical Design of Experiments (DoE) is widely recognized as the most effective approach for process development.
Application of this technique can take a long time – weeks or even months – unless the right experimental tools are available so that quality results can be obtained at speed. The best tools consist of multiple reactors that can work in parallel as well as independently with accurate control and logging of all key parameters.
HEL has a range of parallel chemistry platforms (4 and 8 reactor set ups as standard) which include applications such as:
-Heterogeneous catalysis under pressure (e.g for hydrogenations) – HP ChemScan
-General synthetic chemistry at wide temperature ranges in compact footprint – PolyBlock
-More challenging set of controls and/or extreme working range and flexibility – AutoMate II
These systems are fully computer controlled and if necessary can be linked directly to the DoE software so that process conditions can be easily entered for the different runs. This is the first step towards eventually having a closed loop optimisation platform.
Click HERE to download our white paper (in conjunction with the University of Nottingham) on the:
“Conversion of isophorone to trimethylcyclohexanone”, which highlights the application of DoE
software, for the optimisation of continuous flow hydrogenation
copy and paste this link: http://bit.ly/heldoe1
HEL will be exhibiting at the upcoming The Battery Show in Novi, Michigan on September 15th through 17th. The show is a premier event showcasing the latest advancements in battery technology.
Please stop by out booth (1843) and discover the latest developments in battery safety testing equipment, including the:
HEL BTC Range Of Adiabatic Battery Testing Calorimeters (BTC)
The BTC determines safe working limits to avoid thermal runaway explosion under ‘worst case’ (adiabatic) conditions it provides data that can be relied upon in real-life applications. The limits can only be measured with an adiabatic device, any other system will not provide safe operating values.
isothermal-Battery Testing Calorimeters (iso-BTC)
The isoBTC provides heat-release profile during battery charge/discharge, at a constant temperature. Data for battery development, thermal management and performance modelling, at different temperature
HEL products for Heterogeneous catalyst screening and highpressure process development at the moment go from the very basic (such as CAT7, 18 and 24) with each sample at exactly the same conditions and no data logging at one extreme and then HP Chemscan at the other end, which is fully automated system with individually controlled sample conditions.
The price difference between these two extreme is also very large and for this reason HEL is introducing the PolyCAT.
This versatile new product is most definitely at the high automation and data logging end of the spectrum but some simplifications have enabled us to cut the price by some 30% compared to HP Chemscan. The same compact footprint and ease of use as the HP Chemscan, this too will offer 8×16 ml reactors as standard, all fully stirred with individual temperature control and graphical data display on PC as standard.
Download our brochure bit.ly/polyCAT8
The scalability study was based on matching kLa values in both a 100 ml miniature bioreactor and a 2L bioreactor. The table below illustrates how closely the biomass concentration and DOT profiles compare at the two scales, with µmax values that differ by only 0.03 h-1. A greater final biomass concentration, 5.5 g.L-1, was produced in the 2 L bioreactor as a significantly larger initial inoculum, 6.7%, was used. The trends for oxygen depletion during the linear growth phase as well as time taken for both systems to become oxygen limited are similar and reproducible in both cases.
This data quality at approximately 100 ml scale combined with the miniature electronics has resulted in the most compact, high throughput bioreactor platform available, with a range of features previously only possible at large scale.
Download our full brochure bit.ly/xplorerht