Very Successful 2016 HEL User Group Meeting, In Goa India

HEL 2016 User, group meeting in Goa IndiaOn February 25th and 26th 2016 – Goa, India HEL held its very successful Process Development Conference & Workshop.
At this prestigious event, we attracted over 50 participants, with 15 industry leaders, giving their expert insights in process development.
The topics included :
– Supercritical drying for best thermal insulators
– High-pressure fermentor for deep-sea microbial cultivation
– Quality by design : trends in generic API pocess development
– Application of PolyBLOCK system to biologics process
– Mixing simulation for scale up & better conversion
– Using DoE during development for the right design
–  Difficult to crystallise scenario
–  Thermal screening and parallel platform in scale-up
– Use of TSU at Aarti Industries for safe scale-up of process
–  Thermal decomposition behaviour of Tri n-butyl phosphate-nitric acid
–  Graduating from ALR to Simular
–  Process intensification- A recent trend in API pharma industries
–  Vent sizing and runaway reactions.

The amazing feedback we got from speakers and participants:

Aniket Gogate of Unichem:    Many informative contents  especially  session  conducted  by  Shravan Kumar  &  Amin on  crystallisation  &  Process intensification respectively .

Mithun  Surve, Lupin: Quite impressive technical  session and got  new  insight  about the  special  AeroGel application by  Dr. Neha  of  ARCI and nuclear research  & safety by Dr. Chandran  of  IGCAR .

Subramani  Ramesh Babu, Eisai: Some of  the  research  work  presented  on deep  sea microbes  studies  by Dr. Kirubagaran of  NIOT  was  fantastic for therapeutic applications .

Ch. Anil Kumar, Divis: We enjoyed the conference and had new learning on Chiral Crystallisation and process safety aspects with vent  sizing .

Raosaheb  Kalyankar, Daiichi  Sankyo: The concept of Mixing simulation & DOE software for  process optimisation was something  I liked   most for my synthetic research work

Dr. Neha, ARCI: Enjoyed the conference  and stay in Goa . Great to meet people and listen to so many different aspects of HEL automation & applications .

Mr. Amin Ismaili, Alembic: Well organised conference and selection of speakers  & their topics provided greater insight about their research work. I enjoyed  the program thoroughly and  look forward  to  HEL  event  which I found better in the content compared  to others.

Dr. Deepak, Jain Zoetis: The theme based program made stunning  impact the on not only audience but to speakers as well in order to look beyond what Pharma world  is doing. Excellent support by HEL team whenever I needed  them.

Dr.  Madhavan Buddha, Biocon: It has been a memorable experience all the way and I am very impressed on NIOT work with deep-sea microbial research presented by Dr. Kirubagaran .

Dr. Chandran, IGCAR: I liked the program structure and the audience interaction by asking different questions on almost all the topics presented

Mr. Shravan Chandrashekar,DRL: The Goa conference just provided enough food for our thoughts while dealing with our process research work and role of automation in achieving QbD objectives .

The presentation by  Shravan( Dr.  Reddy ), Deepak (  Zoetis ), Neha ( ARCI ) has been widely appreciated by all the participants .

The presentation by Amin, forced audiences to think how the basic of chemical engineering can help engineering the chemistry & development activities.

HEL 2016 User, group meeting in Goa India HEL 2016 User, group meeting in Goa India HEL 2016 User, group meeting in Goa India

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The NEW Bioreactor Inventory Control (BIC)

The Bioreactor Inventory Control (BIC) constantly measures ONLY the volume of the bioreactor contents. The BIC is also immune to effects of foaming that can  hinder accurate level detection. The BIC technology can be easily added to any  reactor, either to the head plate or remote from the bioreactor, and is the size of a  matchbox. The control of culture volumes in bioreactors is critical to ensure optimum conditions for cell growth and to achieve high cell densities.

HEL has developed a system that is based on proven technology but is more traditionally used with large scale fermenters.
The Bioreactor Inventory Control (BIC) constantly measures ONLY the volume of the bioreactor contents. The BIC is also immune to effects of foaming that can hinder accurate level detection. The BIC technology can be easily added to any reactor, either to the head plate or remote from the bioreactor, and is the size of a matchbox.

The system can accurately maintain the volume of any bioreactor regardless of size or culture medium. It’s design also allows easy adaption to HEL’s parallel mini-reactors, where loss of material is often critical.

NOW SHOWING Our Webinar Innovations In Miniature Bioreactor Technology

The webinar shows HEL innovative screening technology developed for Gas fermentation:

  • Miniature bioreactors from 20 ml to 500 ml that can be operated in parallel at pressures to 10 bar.

  • Proven scalability based on classical bioreactor design and geometry

  • Advanced gas management methods

  • Full automation from inoculation to sampling and downstream processing

  • How to configure a system for C1 gas process development

 

To download pdf of this webinar, click here

The Next Step In Flow Chemistry Under Pressure : The FlowCAT SA

The Next Step In Flow Chemistry Under Pressure : The FlowCAT SA

Contrary to popular belief, “Flow Chemistry” has extensively been used in small scale chemical production for decades, especially for chemistry under pressure.
The HEL FlowCAT is a bench-top platform enabling continuous flow heterogeneous catalysis for use in applications including hydrogenation, carbonylation, oxidation and is widely used in the pharmaceutical and fine chemical industries.
In response to customer requests, a lower price platform is now being launched – The FlowCAT SA.
The FlowCAT SA provides a more focused set of working conditions, and the control is semi-automated (hence “SA”). The compact mechanical design is of the same quality and robustness (of the original FlowCAT), but working pressure and the temperature are defined using local digital controllers (instead of through software).
Liquid-gas reactions at quite extreme conditions (up to 300 ⁰C and 100 bar) are supported. The maximum operating conditions for the FlowCAT SA are lower than for the automated FlowCAT, which is more than adequate for most processes.
The FlowCAT SA is an excellent addition to any lab for around half the price of the standard FlowCAT.

 

Reactor Sampling – 24 Hours Continuous Sampling With The Automatic Sampling Unit (ASU)

Reactor sampling 24 hours a day

Reactor Sampling (and then diluting/quenching) at exact definedHEL Automated Screening Unit for reactor sampling, 24 hours a day times both day and night are now possible with a compact
(~ 25 (l) x 27.1 (h) x 17.5 (w) cm) portable Automated Sampling Unit (ASU), on both small and large reactors.
A recent design change has enabled the cost to be reduced without any compromise in features:
| No cross-contamination between samples
| Wetted parts PTFE/glass
| Consumable costs virtually zero
| Essentially no preparation and setup time

more info

HEL at RAFT 2015

HEL are exhibiting at RAFT (Recent Advances in Fermentation Technology), an annual SIMB event.
November 8- 11, 2015
Location: Hilton Clearwater Beach Hotel, Clearwater Beach, FL
We will be showing our latest innovations in bioreactor solutions which offers the most compact parallel screening systems available with working volumes from 20 ml to 2. 5 L and with pressure capabilties up to 5 barHEL Bioreators

Research Scale Pressure Reactors

The need for “tool-less” leak tight seals

The mini range of High pressure reactorsDemanding chemistries often require more extreme process conditions which need pressure reactors. A key to doing chemistry under pressure is to use reactors that are simple to use while at the same time being safe – covering single and parallel operation and a over a range of volumes.
At the small volume end, HEL has developed “Research Scale” Pressure Reactors where a range of volumes can fit a single heat plate:

Mini: Common head plate to fit 16,25 and 50 ml – magnetically stirred
Midi: Common head plate to fit 75, 150, 300 and 500 ml – magnetically or overhead stirred.
These reactors, which are fully PED compliant with a working range of up to 200 Bar and 300 0C, have multiple ports for a range of probes and can even be just hand tightened to achieve leak-tight seals.
The common head plate design is similar to our existing concept for bench and floor standing reactors, where volumes from 500 ml to 20 L can be interchangeably used on the same head. This provides a compact floor or bench-standing frame, that can take reactors over this wide volume without any need to change the head plate, pressure fittings, stirrer motor etc. Even pressure glass vessels can be used on this same head plate in place of metal reactors.

Download our brochure
or copy and paste this link: http://bit.ly/HPreactors

The BioVIS – Total Cell Density & Biomass Monitoring In Any Bioreactor

The BioVIS From Magellan BioTech For The Real-Time Total Cell Density & Biomass Monitoring In Any Bioreactor

The BioVIS from Magellan BioTech (a HEL group company) offers the following unique features:

Ease Of Operation
BioVIS allows the online monitoring of total cell growth and biomass using optical density technology, which can reduce or replace the need for online sampling.
Simply insert the sterilisable probe inside the bioreactor and track growth.

Compatible With All Major Brands Of Bioreactors
This is a compact, portable and easy to use unit which is compatible with all major brands of
bioreactor, including:
– Sartorius Stedim
– Applikon
– Pierre Guerin
– Finesse
– Infors
– New Brunswick
And many more ………

Features

  • Monitor and log total cell density in any fermenter
  • Plug and Play design for use with any bioreactor
  • Proprietary light reflectance technology
  • Probe lengths for any size vessel
  • Single compact portable unit sample
  • No need for sampling and dilutions
  • No reduction in medium volume due to sampling
  • Integrated data logging option available with further temperature and pH monitoring functions
  • Data is comparable to that produced by a spectroscope, but at a fraction of the cost!
  • The BioVIS measurement shows a good correlation with the off-line analysis, and has all the advantages of being on-line.

For more information on the BioVIS:

Visit the Magellanbiotech.com website
or
download BioVIS brochure (pdf)

The BioVIS
BioVIS allows the online monitoring of total cell growth and biomass using optical density technology, which can reduce or replace the need for online sampling.
Manufacturer: HEL

Hybrid Reactor Solutions For Bioreactors And Catalytic Synthetic Chemistry

HEL ChemSCAN For Catalyst, Bio & Chemical ApplicationsHEL ChemSCAN For Catalyst, Bio & Chemical Applications

HEL offer reactors used for  “green” fuels (bio-diesel, bio-ethanol etc.), as well as bioreactors for cell and bacterial applications.
These bio applications have a lot in common with high-pressure solutions for synthetic chemical screening and hydrogenation processes. The switch to 2nd and 3rd  generation bio-fuels (using biomass sources such as food-waste, stalks from crop, etc.) requires more extreme temperatures and pressures, not unlike heterogeneous catalytic processes.

HEL’s unique position as both a bio and synthetic chemistry supplier is allowing the growing number of cross-over applications to be readily satisfied.
Download our full brochure at http://bit.ly/HELhighpressure

HEL Versatile Pressure Reactor Systems For Screening Up To 200 bar

Versatile Pressure Reactor Systems For Screening Up To 200 bar

HEL October 2015 Events In The Far East

HEL Events In China and Korea

HEL will be attending two prestigious events in the far east, during October 2015. These will be attended by HEL’s CEO- Dr. Jasbir Singh, who will be giving detailed presentations on safety and battery related matters.

Events details:

The 2015 Annual Conference of Chemical Industry and Engineering Society of China (CIESC)
Date:                           16th – 18th October 2015
Location:                    The Beijing Convention Center, Beijing, China
Presentation Given: Safe Scale-up of Hazardous Chemical Reactions
This will cover the generation of data necessary for understanding reaction hazards (based on isothermal and adiabatic calorimeters) and how this information can then used to develop safe processes.  Efficient and rapid process scale-up will also be considered taking into account both the need for safety and product quality.

The Battery Conference 2015
Date:                            21st-22nd October
Location:                    Coex Grand Ballroom, Seoul, Korea
Presentation Given:  Prediction of Battery Thermal Runaway Hazard and Cooling Requirements Using Combined Calorimetry Methods
This will cover description of how and why thermal runaway hazards arise in modern batteries and what can be done to prevent these problems. Included will be a discussion of special calorimeters to provide an understanding battery “abuse” problems as well as how to obtain key heat generation rate data, needed to design thermal management systems.

For a list of all our events