NOW SHOWING Our Webinar Innovations In Miniature Bioreactor Technology

The webinar shows HEL innovative screening technology developed for Gas fermentation: Miniature bioreactors from 20 ml to 500 ml that can be operated in parallel at pressures to 10 bar. Proven scalability based on classical bioreactor design and geometry Advanced gas management methods Full automation from inoculation to sampling and downstream processing How to configure a system for C1 gas process development   To download pdf of this webinar, click here

Reactor Sampling – 24 Hours Continuous Sampling With The Automatic Sampling Unit (ASU)

Reactor sampling 24 hours a day Reactor Sampling (and then diluting/quenching) at exact defined times both day and night are now possible with a compact (~ 25 (l) x 27.1 (h) x 17.5 (w) cm) portable Automated Sampling Unit (ASU), on both small and large reactors. A recent design change has enabled the cost to be reduced without any compromise in features: | No cross-contamination between samples | Wetted parts PTFE/glass | Consumable costs virtually zero | Essentially no preparation and setup time more info

Research Scale Pressure Reactors

The need for “tool-less” leak tight seals Demanding chemistries often require more extreme process conditions which need pressure reactors. A key to doing chemistry under pressure is to use reactors that are simple to use while at the same time being safe – covering single and parallel operation and a over a range of volumes. At the small volume end, HEL has developed “Research Scale” Pressure Reactors where a range of volumes can fit a single heat plate: Mini: Common head plate to fit 16,25 and 50 ml – magnetically stirred Midi: Common head plate to fit 75, 150, 300 and 500 ml – magnetically or overhead stirred. These reactors,… Continue Reading

Hybrid Reactor Solutions For Bioreactors And Catalytic Synthetic Chemistry

HEL ChemSCAN For Catalyst, Bio & Chemical Applications HEL offer reactors used for  “green” fuels (bio-diesel, bio-ethanol etc.), as well as bioreactors for cell and bacterial applications. These bio applications have a lot in common with high-pressure solutions for synthetic chemical screening and hydrogenation processes. The switch to 2nd and 3rd  generation bio-fuels (using biomass sources such as food-waste, stalks from crop, etc.) requires more extreme temperatures and pressures, not unlike heterogeneous catalytic processes. HEL’s unique position as both a bio and synthetic chemistry supplier is allowing the growing number of cross-over applications to be readily satisfied. Download our full brochure at

New Bioreactor Solutions, Provides 5 Times The Productivity Of Conventional Reactors

FREE WHITE PAPER DOWNLOAD Robotic culture platform with HEL minibioreactors Parallel platforms can also be integrated with bioreactors – hence 4 or 8 reactor parallel stations are now possible with a compact footprint that includes all the features of high specification applications – pH, DO, agitation, liquid dosing, independent temperature control. A recent project extended this concept still further with a set of 24 independent reactors for TWB in France, involving the integration of a Hamilton robot and HEL bioreactor system. The final design – a “culture robot” – allows, among other things, identification of optimal culture conditions or generation of successfulstrains, in less than a fifth of the time… Continue Reading

DoE using Parallel Automated Reactor Systems- FREE White Paper

Statistical Design of Experiments (DoE) is widely recognized as the most effective approach for process development. Application of this technique can take a long time – weeks or even months – unless the right experimental tools are available so that quality results can be obtained at speed. The best tools consist of multiple reactors that can work in parallel as well as independently with accurate control and logging of all key parameters. HEL has a range of parallel chemistry platforms (4 and 8 reactor set ups as standard) which include applications such as: -Heterogeneous catalysis under pressure (e.g for hydrogenations) – HP ChemScan -General synthetic chemistry at wide temperature ranges… Continue Reading

HEL At The The Battery Show – 15-17th September 2015

HEL will be exhibiting at the upcoming The Battery Show in Novi, Michigan on September 15th through 17th.  The show is a premier event showcasing the latest advancements in battery technology. Please stop by out booth (1843) and discover the latest developments in battery safety testing equipment, including the: HEL BTC Range Of Adiabatic Battery Testing Calorimeters (BTC) The BTC determines safe working limits to avoid thermal runaway explosion under ‘worst case’ (adiabatic) conditions it provides data that can be relied upon in real-life applications. The limits can only be measured with an adiabatic device, any other system will not provide safe operating values.       isothermal-Battery Testing Calorimeters (iso-BTC)… Continue Reading

CATalyst Screening – EXPANDING The Product Range With The HEL PolyCAT

HEL products for Heterogeneous catalyst screening and highpressure process development at the moment go from the very basic (such as CAT7, 18  and 24) with each sample at exactly the same conditions and no data logging at one extreme and then HP Chemscan at the other end, which is  fully automated system with individually controlled sample conditions. The price difference between these two extreme is also very large and for this reason HEL is introducing the PolyCAT. This versatile new product is most definitely at the high automation and data logging end of the spectrum but some simplifications have enabled us to cut the price by some 30% compared to… Continue Reading

Scalability Study With The HEL Xplorer Bioprocessing Platform

HEL Bioreators

The scalability study was based on matching kLa values in both a 100 ml miniature bioreactor and a 2L bioreactor. The table below illustrates how closely the biomass concentration and DOT profiles compare at the two scales, with µmax values that differ by only 0.03 h-1. A greater final biomass concentration, 5.5 g.L-1, was produced in the 2 L bioreactor as a significantly larger initial inoculum, 6.7%, was used. The trends for oxygen depletion during the linear growth phase as well as time taken for both systems to become oxygen limited are similar and reproducible in both cases. This data quality at approximately 100 ml scale combined with the miniature… Continue Reading