The new Tandem gas analyser data capture software allows the convenient monitoring and visualisation of exhaust gas data from all Tandem Gas Analysers Advantages of the Tandem data capture software: | Real-time monitoring of %CO2 and %O2 from the off-gas of any bioreactor | Export data in CSV format | Available as a stand-alone portable unit | Works with any Tandem gas analyser | Run up to 18 parallel processes | Simple to use | Automatically calculates CER, OUR & RQ with HEL BioXplorer systems The Tandem Family of Gas Analysers offers you sophisticated CO2 and O2 gas measurement at a similar price to your other standard probes and… Continue Reading
Fast Optimisation & Safe Scale-up – Simular Reaction Calorimeter Essential tool for process development chemists HEL’s reaction calorimetry system provides a unique blend of features that are considered indispensable for process development: | Automation accelerates development, freeing up chemist time | Repeatable runs independent of operator | Ease of use including automatic on-line heat release rate results | Directly enables prediction of cooling duty, thermal hazard and possible methods for risk reduction The Simular is based around reaction vessels that are easy to use but also match the geometry and performance of large-scale vessels. Designs are available to suit a range of pressures and temperatures.
Change In Design For CAT 7 Cold fingers have been removed (unscrewed) and silicone seals no longer used. Instead, special PTFE plugs are placed in each vial. This is the only change. Why Change?- The Benefits Solvent loss from vials during an experiment is much reduced and reproducibility is improved. Also, chemical compatibility is improved by removal of silicone seals and use of only PTFE. The operation remains simple. Older CAT 7 Units Existing CAT7 units can be updated easily. Cold fingers must be unscrewed by the user (easily done by hand) and a set of PTFE plugs purchased.
Introducing The BioXplorer 100 & BioXplorer 400 Mini-Bioreactor System The feature rich, modular design with an extensive list of options means the BioXplorer 100 and 400 can be adapted to any application including microbial fermentation, C1 Gas fermentation and mammalian cell culture. These mini-bioreactors provide the ideal platform for bioprocess development and optimisation using 4 or 8 reactors in parallel with fermentation working volumes from 20 ml to 400 ml (depending on c.onfiguration) The BioXplorer 100 The BioXplorer 100 is a high throughput, bioprocess screening system designed for fermentation working volumes of just 20ml to 150ml in blocks of 8 individually controlled bioreactors. Blocks can be combined to give even… Continue Reading
DOWNLOAD OUR FREE APPLICATION NOTE HIGHLIGHTING KPI’S FOR THERMAL CONTROL DATA BASEDON ISOTHERMAL CALORIMETRY General Motors (GM) recently purchased an iso-BTC after extensive trials with their batteries samples, even though they have adiabatic calorimeters available to them. Here’s why. Fires and explosions involving Li-ion batteries occur when heat is not removed effectively and leads to a rise in temperature. Thermal management systems are designed to prevent such incidents but can only do so if they are designed to handle the necessary heat load – which raises the question: how can this load be determined? The answer is HEL’s iso-BTC, which works exactly like a thermal management system except it reports… Continue Reading
This webinar focuses on the use of multiple (parallel) reactor platforms, which is becoming an established practice in pharma and other sectors as well as the use of DoE to direct the experimental effort and analyze the data. The webinar also highlights the results of many different process development studies to illustrate the range of parallel reaction instruments available. Examples from synthetic organic chemistry in general, as well as heterogeneous catalysis (including hydrogenation in flow reactors) and crystallization studies, are used to describe the benefits of these techniques. To Download PDF Of This Webinar, please click on this link
Faster and Better Process Development Using Parallel Reactor Platforms and DoE. Competitive pressures within the chemical process industry require that more processes be developed quickly and with better results. The use of multiple (parallel) reactor platforms is becoming an established practice in pharma and other sectors as well as the use of DoE to direct the experimental effort and analyze the data. This webinar will present the results of many different process development studies to illustrate the range of parallel reaction instruments available. Examples from synthetic organic chemistry in general, as well as heterogeneous catalysis (including hydrogenation in flow reactors) and crystallization studies, will be used to describe the benefits… Continue Reading
Pressure relief of chemical reactors is the accepted way to prevent explosive vessel rupture in the event of a control problem such as loss of cooling supply or agitation failure. When the problem leads to a runaway reaction, potentially leading to rapid rises in temperature and pressure, correct sizing of the pressure relief device becomes much more critical due to the potential severity of the incident but also more difficult as it requires an accurate description of the runaway event. The underlying technology for this was established ~ 1985 through a multi-company initiative (called DIERS). In addition, the need for small-scale simulation of the runaway reaction was established and the… Continue Reading
On February 25th and 26th 2016 – Goa, India HEL held its very successful Process Development Conference & Workshop. At this prestigious event, we attracted over 50 participants, with 15 industry leaders, giving their expert insights in process development. The topics included : – Supercritical drying for best thermal insulators – High-pressure fermentor for deep-sea microbial cultivation – Quality by design : trends in generic API pocess development – Application of PolyBLOCK system to biologics process – Mixing simulation for scale up & better conversion – Using DoE during development for the right design – Difficult to crystallise scenario – Thermal screening and parallel platform in scale-up – Use of… Continue Reading
The webinar shows HEL innovative screening technology developed for Gas fermentation: Miniature bioreactors from 20 ml to 500 ml that can be operated in parallel at pressures to 10 bar. Proven scalability based on classical bioreactor design and geometry Advanced gas management methods Full automation from inoculation to sampling and downstream processing How to configure a system for C1 gas process development To download pdf of this webinar, click here