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A versatile continuous flow reactor system
This article explains the functionality and gives examples of the FlowCAT - versatile continuous flow reactor system focusing on reactions under elevated pressure and/or involving heterogeneous catalysis. The utility of a versatile, research scale flow reactor has been demonstrated with numerous reactions. In addition, the FlowCAT is extremely simple to and opens up the possibility of doing pressure reactions, including hydrogenations, in normal laboratories by chemists who are not specialists in pressure equipment. The flowCAT allows all manner of chemistries to be studied interchangeably with virtually no change in set up being necessary. Feeds of all liquid, all gas and mixtures of gas and liquid are possible and the same is true for products.
The FlowCAT represents a freely-configurable platform on which to build versatile, automated systems for Flow Chemistry. In this example we take a look at a configuration which optimises conversion through liquid recycle.
Application Note-Adapting Catalytic Platforms For Greener Chemistry
Among the other potential benefits of moving to fixed bed flow reactors, is the ease with which benefits of supercritical CO2 (scCO2) can be investigated. HEL has been looking at the hydrogenation of phenol, both on stirred batch platforms (such as HP ChemSCAN) and FlowCAT. Starting with a process documented in the literature, we were able to replicate and extend this easily and quickly using the 8-reactor, 200bar parallel stirred reactor system.
Application Note: FlowCAT for tuning stereoselective hydrogenations of API's
Hydrogenation of organic substrates to achieved desired product slates can be difficult and expensive using conventional stirred reaction. The HEL flowCAT overcomes many difficulties with inherent flexibility, an accessible interface and features for easy use by specialist and non-specialist chemists alike.
Call for Papers: 12th HEL Conference
Catalytic reactions, hydrogenation in particular, have seen a remarkable surge in interest over the last 10 years, most strikingly in the pharmaceutical and fine chemical industries. More recently, flow chemistry has begun to attract a similar level of interest for a wide range of chemistries, but especially involving heterogeneous catalysis. Join the 12th HEL Conference on September 27th 2011, Cambridge, UK, to speak and hear about recent developments in these areas.
Enantio- and Diastereoselective Hydrogenation of Pharmaceutical Intermediates
A presentation from Dr Joel M. Hawkins, Chemical Research and Development at Pfizer PharmaTherapeutics, at the Stereochemistry Gordon Conference, Newport, Rhode Island, August 4, 2010.
FlowCAT - continuous flow reactor system for hydrogenation screening and small scale production
A presentation given by Dr Jasbir Singh at the Chemistry Today 2nd Symposium on Continuous Flow Reactor Technology for Industrial Applications, about the developments of the FlowCAT system, including performance data and examples of the use of DOE with hydrogenation reactions, carried out on a continuous flow reactor. Have a look at the presentation that includes data recently presented by Dr Joel Hawkins of Pfizer.