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Application Note: The Development of Solubility and Metastability Design Spaces
UCD Crystallization Research Group found that the HEL polyblock turbidity screening device, when combined with polythermal methods, enhances process understanding and enhances quality by design (QbD). By gaining a understanding of the limitations and benefits of a solubility and metastability design space a suitable crystallization technique can be designed.
Automated Measurement of Metastable Zones for Pharmaceutical Compounds
The automated laboratory reactor combined with turbidity meter method was used successfully to measure the metastable zone for a pharmaceutical intermediate, thus providing useful information to aid the development of the crystallization process for that compound.
Crystallisation Tools for the Research Chemist
It is clear that crystallisation studies in parallel can be performed at sample sizes as low as 1ml or as large as several hundred millilitres. The data scales up reliably and thus provides an excellent early insight into the key variables. This article expands the functionality and applications of CrystalSCAN and Crystal Eyes from HEL.
Laboratory Product Focus: Crystallisation Tools for the Research Chemist
The need to study crystallisation is extremely widespread in the chemical industry due to the importance of solids as the final form of many products. The most basic information required is the solubility of crystals - proceeding without this basic information is like trying to locate a house without knowing the address - it can be done but will take a long time.
Minimisation of Scale-up Difficulties
This article discusses what chemists and engineers can do in advance, both in the laboratory and kilo laboratory, to prevent or at least minimise scaleup issues. Scale-up of chemical processes, particularly those involving batch or semi-batch manufacture is well-known to be a problematic area of chemistry and chemical engineering, and can be costly when it goes wrong. By correctly choosing and designing the synthetic route to a fine chemical or drug substance, as well as controlling the reaction and work up/product isolation parameters, many of the difficulties in scale up can be avoided. The more complex a process is in terms of chemistry and unit operations, the more there is to go wrong.