Rapid Process Development and Scale-Up Using A Multiple Reactor System
This article presents case studies that show how computer control involving parallel synthesis in specially designed reactors, particularly on the 25-100 mL scale, can provide significant benefits to the development cycle of new synthetic compounds of commercial interest. By employing a combination of calorimetry data and other analytical measurements, it has been demonstrated that small-scale experimentation can produce data that is both representative and scaleable.